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Toxicogenomics in drug discovery and development:: mechanistic analysis of compound/class-dependent effects usign the DrugMatrix® database

被引：92
作者：
Ganter, Brigitte
Snyder, Ronald D.
Halbert, Donald N.
Lee, May D.
机构：
[1] Iconix Biosci, Mountain View, CA USA
[2] Schering Plough Res Inst, Summit, NJ USA
来源：
PHARMACOGENOMICS | 2006年 / 7卷 / 07期
关键词：
drug discovery and development; inducible nitric oxide synthase; mechanism of action; mechanism of toxicity; microarray expression data; CYP gene expression; phosphodiesterase inhibitors; RXR protein function; toxicogenomics;
D O I：
10.2217/14622416.7.7.1025
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A range of genomics technologies are increasingly becoming integrated with existing scientific disciplines to broaden and strengthen existing capabilities and open new avenues of research in drug discovery and development. Examples of these new research fields are proteomics, pharmacogenomics, metabolomics and toxicogenomics. Here we review the application of toxicogenomics to improve the evaluation of drug safety, mechanism of action and toxicity in the drug discovery and development process.
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收藏
页码：1025 / 1044
页数：20
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