S100B protein in carbon monoxide poisoning: a pilot study

被引：33

作者：

Brvar, M

Mozina, H

Osredkar, J

Mozina, M

Noc, M

Brucan, A

Bunc, M

机构：

[1] Sch Med, Inst Pathophysiol, Ljubljana 1000, Slovenia

[2] Ljubljana Med Ctr, Clin Dept Cardiol, Ljubljana 1000, Slovenia

[3] Ljubljana Med Ctr, Dept Emergency Med, Ljubljana 1000, Slovenia

[4] Ljubljana Med Ctr, Ctr Intens Internal Med, Ljubljana 1000, Slovenia

[5] Ljubljana Med Ctr, Poison Control Ctr, Ljubljana 1000, Slovenia

[6] Ljubljana Med Ctr, Lab Biochem Anal, Ljubljana 1000, Slovenia

[7] Ljubljana Med Ctr, Ctr Intens Internal Med, Ljubljana 1000, Slovenia

[8] Ljubljana Med Ctr, Poison Control Ctr, Ljubljana 1000, Slovenia

来源：

RESUSCITATION | 2004年 / 61卷 / 03期

关键词：

carbon monoxide; hyperbaric oxygen; S100B; indications; prognosis;

D O I：

10.1016/j.resuscitation.2004.01.009

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Carbon monoxide (CO) poisoning is the most common form of lethal poisoning. The aim of this prospective clinical study was to assess the possible role of S100B, the structural protein in the astroglia, as a biochemical marker of brain injury in carbon monoxide poisoning. Serum S100B determination was performed in 38 consecutive patients poisoned by carbon monoxide who were admitted to the Emergency Department (ED) in Ljubljana. All three unconscious patients had elevated S100B levels. The patient with the highest S100B died. S100B was elevated in two of the six patients with initial transitory unconsciousness at the scene. All 29 patients without loss of consciousness had normal S100B levels. Carbon monoxide poisoning appears to be associated with elevated S100B levels. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：357 / 360

页数：4

共 13 条

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