Enantioselective formal synthesis of uleine alkaloids from phenylglycinol-derived bicyclic lactams

被引：26

作者：

Amat, M ^{[1
]}

Pérez, M

Llor, N

Martinelli, M

Molins, E

Bosch, J

机构：

[1] Univ Barcelona, Fac Pharm, Organ Chem Lab, E-08028 Barcelona, Spain

[2] CSIC, Inst Ciencia Mat, Cerdanyola Del Valles 08193, Spain

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 14期

关键词：

D O I：

10.1039/b400987h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A two-step route for the enantioselective construction of the tetracyclic ring system of uleine alkaloids, involving the stereoselective conjugate addition of an appropriate indole-containing nucleophile to a chiral bicyclic delta-lactam and the subsequent cyclization on the indole 3-position of the resulting 4,5-disubstituted 2-piperidone, has culminated in the formal total synthesis of several alkaloids of this group.

引用

页码：1602 / 1603

页数：2

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