Ring-Opening Polymerization of DD-Lactide Catalyzed by Novozyme 435

被引：54

作者：

Hans, Marc ^{[1
,2
]}

Keul, Helmut ^{[1
,2
]}

Moeller, Martin ^{[1
,2
]}

机构：

[1] Rhein Westfal TH Aachen, DWI RWTH Aachen eV, D-52056 Aachen, Germany

[2] Rhein Westfal TH Aachen, Inst Tech & Macromol Chem, D-52056 Aachen, Germany

来源：

MACROMOLECULAR BIOSCIENCE | 2009年 / 9卷 / 03期

关键词：

biodegradable; enzymes; ring-opening polymerization; ORGANIC MEDIA; LIPASE; COPOLYMERIZATION; CAPROLACTONE; POLYESTERS;

D O I：

10.1002/mabi.200800236

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In contrast to LLA, DLA is converted in toluene solution under mild reaction conditions (50-70 degrees C) using Novozyme 435 (immobilized CALB) to form the corresponding polymer. The influence of several parameters, such as enzyme concentration, temperature and monomer concentration, on the polymerization rate and the monomer conversion was studied. In contrast to the Novozyme 435 catalyzed polymerization of epsilon-caprolactone, enzyme deactivation occurs. It is attributed to the deprivation of water from the enzyme. This work points out that by careful selection of the reaction conditions, it is possible to obtain poly(D-lactide) in reasonable molecular weights and in high yields using Novozyme 435 catalysis.

引用

页码：239 / 247

页数：9

共 22 条

[1] Recent developments in enzyme-catalyzed ring-opening polymerization [J].