αvβ3-integrin imaging:: a new approach to characterise angiogenesis?

被引：120

作者：

Haubner, Roland ^{[1
]}

机构：

[1] Med Univ Innsbruck, Univ Klin Nukl Med, A-6020 Innsbruck, Austria

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2006年 / 33卷 / Suppl 1期

关键词：

angiogenesis; radiolabelled RGD peptides; integrin alpha(v)beta(3); tracer techniques; molecular imaging;

D O I：

10.1007/s00259-006-0136-0

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Overview: The field of angiogenesis research is one of the most rapidly growing biomedical disciplines. Great efforts are being made to develop anti-angiogenesis drugs for treatment of cancer as well as non-oncological diseases. Thus, imaging techniques allowing non-invasive monitoring of corresponding molecular processes will be of great interest. One target structure involved in the angiogenic process is the integrin alpha(v)beta(3), which mediates the migration of activated endothelial cells during vessel formation. Materials and methods: A variety of radiolabelled RGD peptides have been introduced for monitoring of alpha(v)beta(3) expression using nuclear medicine tracer techniques. Objectives: This review discusses tracer development and highlights some strategies for tracer optimisation. It summarises the preclinical and clinical data and discusses the potential of this class of tracer to characterise angiogenesis.

引用

页码：S54 / S63

页数：10

共 65 条

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