Plasma chitotriosidase activity in multiple sclerosis

被引：26

作者：

Comabella, M. ^{[1
]}

Dominguez, C. ^{[2
,3
]}

Rio, J. ^{[1
]}

Martin-Gallan, P. ^{[2
,3
]}

Vilches, A. ^{[2
,3
]}

Vilarrasa, N. ^{[1
]}

Espejo, C. ^{[1
]}

Montalban, X. ^{[1
]}

机构：

[1] Hosp Univ Vall Hebron, Unitat Neuroimmunol Clin, CEM Cat, Barcelona 12908035, Spain

[2] Hosp Univ Vall Hebron, Mol Biol & Biochem Res Ctr CIBBIM, Barcelona 12908035, Spain

[3] Inst Salud Carlos III, Ctr Biomed Res Rare Dis CIBERER, Barcelona, Spain

来源：

CLINICAL IMMUNOLOGY | 2009年 / 131卷 / 02期

关键词：

Multiple sclerosis; Interferon-beta; Chitotriosidase; Innate immunity; DOUBLE-BLIND; DISEASE; MACROPHAGES; GENE; BETA;

D O I：

10.1016/j.clim.2008.12.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A recent study has shown that chitotriosidase (Chit) may play a rote in the pathogenesis of multiple sclerosis (MS). Plasma Chit activity was investigated in 219 untreated MS patients and 160 healthy controls (HC) by means of a fluorometric enzyme activity assay. Chit activity was also measured in a subgroup of 46 patients following treatment with interferon-beta (IFN beta). Overall, plasma Chit activity was significantly increased in MS patients compared with HC, but no differences were observed between relapsing and progressive clinical forms. In addition, Chit activity was similar between patients during relapse and patients during clinical remission. Treatment with IFN beta was associated with a significant increase in Chit activity compared with untreated patients in both responders and non-responders to treatment. Although these findings suggest a role of Chit in MS, our data do not support an association between plasma Chit activity and MS clinical. course and clinical response to IFN beta treatment. (C) 2008 Etsevier Inc. All rights reserved.

引用

页码：216 / 222

页数：7

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