Sex differences in anxiety and depression clinical perspectives

被引：971

作者：

Altemus, Margaret ^{[1
,2
]}

Sarvaiya, Nilofar ^{[3
]}

Epperson, C. Neill ^{[4
,5
,6
]}

机构：

[1] Cornell Univ, Weill Med Coll, Dept Psychiat, New York, NY 10021 USA

[2] Cornell Univ, Weill Med Coll, Dept Complementary & Integrat Med, New York, NY 10021 USA

[3] Zucker Hillside Hosp, North Shore LIJ Sch Med, Glen Oaks, NY USA

[4] Univ Penn, Perelman Sch Med, Penn Ctr Womens Behav Wellness, Dept Psychiat, Philadelphia, PA 19104 USA

[5] Univ Penn, Perelman Sch Med, Penn Ctr Womens Behav Wellness, Dept Obstet & Gynecol, Philadelphia, PA 19104 USA

[6] Univ Penn, Penn Ctr Study Sex & Gender Behav Hlth, Philadelphia, PA 19104 USA

来源：

FRONTIERS IN NEUROENDOCRINOLOGY | 2014年 / 35卷 / 03期

关键词：

Depression; Anxiety; Sex difference; Development; Puberty; Hormones; POSTTRAUMATIC-STRESS-DISORDER; OBSESSIVE-COMPULSIVE DISORDER; NATIONAL EPIDEMIOLOGIC SURVEY; IV SPECIFIC PHOBIA; LOW-BIRTH-WEIGHT; GENDER-DIFFERENCES; UNITED-STATES; PSYCHIATRIC-DISORDERS; MAJOR DEPRESSION; HPA-AXIS;

D O I：

10.1016/j.yfrne.2014.05.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sex differences are prominent in mood and anxiety disorders and may provide a window into mechanisms of onset and maintenance of affective disturbances in both men and women. With the plethora of sex differences in brain structure, function, and stress responsivity, as well as differences in exposure to reproductive hormones, social expectations and experiences, the challenge is to understand which sex differences are relevant to affective illness. This review will focus on clinical aspects of sex differences in affective disorders including the emergence of sex differences across developmental stages and the impact of reproductive events. Biological, cultural, and experiential factors that may underlie sex differences in the phenomenology of mood and anxiety disorders are discussed. (C) 2014 Published by Elsevier Inc.

引用

页码：320 / 330

页数：11

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