A peptide from corn gluten hydrolysate that is inhibitory toward angiotensin I converting enzyme

被引：77

作者：

Suh, HJ

Whang, JH

Lee, H

机构：

[1] Korea Univ, Coll Hlth Sci, Dept Food & Nutr, Seoul 136703, South Korea

[2] Samsung Everland INC, Yongin 449910, Konggi Do, South Korea

[3] Kyonggi Univ, Dept Food & Biotechnol, Suwon, Konggi Do, South Korea

来源：

BIOTECHNOLOGY LETTERS | 1999年 / 21卷 / 12期

关键词：

angiotensin converting enzyme; corn gluten; peptide inhibitor; Pescalase; protease;

D O I：

10.1023/A:1005688627350

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A peptide (F-4) that inhibits angiotensin I converting enzyme (ACE) was isolated from corn gluten hydrolysate prepared with Pescalase, a serine protease from Bacillus licheniformis. The N-terminal amino acid sequence of F-4 was Pro-Ser-Gly-Gln-Tyr-Tyr, having the IC50 value of 0.1 mM. The peptide (F-4), at 30 mg kg(-1) body weight of rat, antagonized the rat's pressor response to angiotensin I.

引用

页码：1055 / 1058

页数：4

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