Detection and characterisation of human astroviruses in children with acute gastroenteritis in Blantyre, Malawi

被引：26

作者：

Cunliffe, NA

Dove, W

Gondwe, JS

Thindwa, BDM

Greensill, J

Holmes, JL

Bresee, JS

Monroe, SS

Glass, RI

Broadhead, RL

Molyneux, ME

Hart, CA

机构：

[1] Univ Liverpool, Dept Med Microbiol & Genito Urinary Med, Liverpool L69 3GA, Merseyside, England

[2] Univ Malawi, Coll Med, Wellcome Trust Res Labs, Blantyre, Malawi

[3] Univ Liverpool, Coll Med, Wellcome Trust Res Labs, Blantyre, Malawi

[4] Univ Malawi, Coll Med, Dept Paediat, Blantyre, Malawi

[5] Ctr Dis Control & Prevent, Viral Gastroenteritis Sect, Atlanta, GA USA

来源：

JOURNAL OF MEDICAL VIROLOGY | 2002年 / 67卷 / 04期

关键词：

astrovirus; HIV; Malawi;

D O I：

10.1002/jmv.10139

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In a 2-year hospital-based study of paediatric gastroenteritis in Blantyre, Malawi, astroviruses were detected by enzyme immunoassay in 15 (1.9%) of 786 inpatients and in 9 (2.3%) of 400 outpatients. Greater disease severity was noted in children coinfected with human immunodeficiency virus (HIV). Six human astrovirus (HAstV) genotypes were identified, including HAstV-1 (25%), HAstV-2 (21%), HAstV-3 (25%), HAstV-4 (13%), HAstV-5 (4%), and HAstV-8 (13%). Although astroviruses are not major causes of gastroenteritis among children admitted to hospital in Blantyre, concomitant HIV infection appears to be a risk factor for increased severity of disease. (C) 2002 Wiley-Liss, Inc.

引用

页码：563 / 566

页数：4

共 23 条

[1] Detection and genetic differentiation of human astroviruses: Phylogenetic grouping varies by coding region [J].