Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat

被引：528

作者：

Guardia, T ^{[1
]}

Rotelli, AE ^{[1
]}

Juarez, AO ^{[1
]}

Pelzer, LE ^{[1
]}

机构：

[1] Univ Nacl San Luis, Fac Quim Bioquim & Farm, Dept Farm, RA-5700 San Luis, Argentina

来源：

FARMACO | 2001年 / 56卷 / 09期

关键词：

flavonoids; rutin; quercetin; hesperidin; anti-inflammatory activity; adjuvant arthritis;

D O I：

10.1016/S0014-827X(01)01111-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The anti-inflammatory activities of three flavonoids were investigated in rats using the Mizushima et al. model of acute and chronic inflammation. Intraperitoneal administration of rutin, quercetin (flavonols) and hesperidin (flavanone), given at daily doses equivalent to 80 mg/kg, inhibited both acute and chronic phases of this experimental model of inflammation. Rutin was the most active in the chronic phase. (C) 2001 Elsevier Science S.A. All rights reserved.

引用

页码：683 / 687

页数：5

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