The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain

被引:282
作者
GuadanoFerraz, A
Obregon, MJ
StGermain, DL
Bernal, J
机构
[1] CSIC, INST INVEST BIOMED, E-28029 MADRID, SPAIN
[2] DARTMOUTH COLL SCH MED, DEPT MED, LEBANON, NH 03756 USA
[3] DARTMOUTH COLL SCH MED, DEPT PHYSIOL, LEBANON, NH 03756 USA
关键词
D O I
10.1073/pnas.94.19.10391
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Thyroid hormone plays an essential role in mammalian brain maturation and function, in large part by regulating the expression of specific neuronal genes, In this tissue, the type 2 deiodinase (D2) appears to be essential for providing adequate levels of the active thyroid hormone 3,5,3'-triiodothyronine (T3) during the developmental period. We have studied the regional and cellular localization of D2 mRNA in the brain of 15-day-old neonatal rats, D2 is expressed in the cerebral cortex, olfactory bulb, hippocampus, caudate, thalamus, hypothalamus, and cerebellum and was absent from the white matter, At the cellular level, D2 is expressed predominantly, if not exclusively, in astrocytes and in the tanycytes lining the third ventricle and present in the median eminence, These results suggest a close metabolic coupling between subsets of glial cells and neurons, whereby thyroxine is taken up from the blood and/or cerebrospinal fluid by astrocytes and tanycytes, is deiodinated to T3, and then is released for utilization by neurons.
引用
收藏
页码:10391 / 10396
页数:6
相关论文
共 48 条
  • [1] THE EFFECTS OF CONGENITAL HYPOTHYROIDISM USING THE HYT/HYT MOUSE ON LOCOMOTOR-ACTIVITY AND LEARNED BEHAVIOR
    ANTHONY, A
    ADAMS, PM
    STEIN, SA
    [J]. HORMONES AND BEHAVIOR, 1993, 27 (03) : 418 - 433
  • [2] BARRES BA, 1991, J NEUROSCI, V11, P3685
  • [3] ORGANIZATION OF AUDITORY CALLOSAL CONNECTIONS IN HYPOTHYROID ADULT-RATS
    BERBEL, P
    GUADANOFERRAZ, A
    MARTINEZ, M
    QUILES, JA
    BALBOA, R
    INNOCENTI, GM
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1993, 5 (11) : 1465 - 1478
  • [4] THYROID-HORMONES AND BRAIN-DEVELOPMENT
    BERNAL, J
    NUNEZ, J
    [J]. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1995, 133 (04) : 390 - 398
  • [5] BLEIER R, 1972, STRUCTURAL RELATIONS, P306
  • [6] BRADLEY DJ, 1992, J NEUROSCI, V12, P2288
  • [7] CONGENITAL HYPOTHYROIDISM, AS STUDIED IN RATS - CRUCIAL ROLE OF MATERNAL THYROXINE BUT NOT OF 3,5,3'-TRIIODOTHYRONINE IN THE PROTECTION OF THE FETAL BRAIN
    CALVO, R
    OBREGON, MJ
    DEONA, CR
    DELREY, FE
    DEESCOBAR, GM
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (03) : 889 - 899
  • [8] IMMUNOFLUORESCENT LOCALIZATION OF THYROID-HORMONE RECEPTOR ISOFORMS IN GLIAL-CELLS OF RAT-BRAIN
    CARLSON, DJ
    STRAIT, KA
    SCHWARTZ, HL
    OPPENHEIMER, JH
    [J]. ENDOCRINOLOGY, 1994, 135 (05) : 1831 - 1836
  • [9] TRANSECTED AXONS OF ADULT HYPOTHALAMONEUROHYPOPHYSEAL NEURONS REGENERATE ALONG TANYCYTIC PROCESSES
    CHAUVET, N
    PARMENTIER, ML
    ALONSO, G
    [J]. JOURNAL OF NEUROSCIENCE RESEARCH, 1995, 41 (01) : 129 - 144
  • [10] GENOMIC SEQUENCING
    CHURCH, GM
    GILBERT, W
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (07): : 1991 - 1995