A melanocortin agonist reduces neuronal firing rate in rat hypothalamic slices

被引：17

作者：

Fong, TM ^{[1
]}

Van der Ploeg, LHT ^{[1
]}

机构：

[1] Merck Res Labs, Dept Obes Res, Rahway, NJ 07065 USA

来源：

NEUROSCIENCE LETTERS | 2000年 / 283卷 / 01期

关键词：

hypothalamus; slice; firing rate; melanocortin; serotonin; neuropeptide Y;

D O I：

10.1016/S0304-3940(00)00823-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bath application of cr-melanocyte stimulating hormone (alpha-MSH) to rat hypothalamic slices inhibited the spontaneous firing rate of continuously firing neurons in the ventromedial hypothalamic nucleus or paraventricular nucleus. This inhibitory effect is most likely direct and independent of synaptic transmission. The cr-MSH-responsive neurons tested did not respond to neuropeptide Y (NPY) application. On the other hand, a-MSH did not inhibit the intraburst firing rate of phasic bursting neurons, although these bursting neurons were highly responsive to a serotonin 5HT2a/2b/2c agonist with a change of firing pattern to continuous firing and an increase in firing rate which was reversed by NPY. These results suggest that a change of neuronal firing rate may represent a neural correlate of satiety induced by anorexic agents. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：5 / 8

页数：4

共 18 条

[1] NEUROPEPTIDE-Y IN THE HYPOTHALAMUS - EFFECT ON CORTICOSTERONE AND SINGLE-UNIT ACTIVITY [J].