Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantaion

被引：1374

作者：

Huetter, Gero ^{[1
]}

Nowak, Daniel ^{[1
]}

Mossner, Maximilian ^{[1
]}

Ganepola, Susanne ^{[1
]}

Muessig, Arne ^{[1
]}

Allers, Kristina ^{[2
]}

Schneider, Thomas ^{[2
]}

Hofmann, Joerg ^{[3
]}

Kuecherer, Claudia ^{[4
]}

Blau, Olga ^{[1
]}

Blau, Igor W. ^{[1
]}

Hofmann, Wolf K. ^{[1
]}

Thiel, Eckhard ^{[1
]}

机构：

[1] Charite Univ Med Berlin, Dept Med 3, Dept Hematol Oncol & Transfus Med, D-12203 Berlin, Germany

[2] Charite Univ Med Berlin, Dept Gastroenterol Infect Dis & Rheumatol, D-12203 Berlin, Germany

[3] Charite Univ Med Berlin, Inst Med Virol, D-12203 Berlin, Germany

[4] Robert Koch Inst, D-1000 Berlin, Germany

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2009年 / 360卷 / 07期

关键词：

BONE-MARROW-TRANSPLANTATION; IMMUNODEFICIENCY-VIRUS TYPE-1; ACTIVE ANTIRETROVIRAL THERAPY; PERIPHERAL-BLOOD; HIGH-RISK; INFECTION; LOAD; PERSISTENCE; POPULATION; LEUKEMIA;

D O I：

10.1056/NEJMoa0802905

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a CD4 receptor and a chemokine receptor, principally chemokine 5 (CCR5). Homozygosity for a 32-bp deletion in the CCR5 allele provides resistance against HIV-1 acquisition. We transplanted stem cells from a donor who was homozygous for CCR5 delta32 in a patient with acute myeloid leukemia and HIV-1 infection. The patient remained without viral rebound 20 months after transplantation and discontinuation of antiretroviral therapy. This outcome demonstrates the critical role CCR5 plays in maintaining HIV-1 infection.

引用

页码：692 / 698

页数：7

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