Synthesis of medicinally interesting 2,4-diamino-9H-pyrimido[4,5-b]indol-6-ols via extension of the Nenitzescu reaction

被引：14

作者：

Dotzauer, B ^{[1
]}

Troschütz, R ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Emil Fischer Ctr, Dept Med Chem, D-91052 Erlangen, Germany

来源：

SYNLETT | 2004年 / 06期

关键词：

N-heterocycles; cyclizations; Nenitzescu reaction; 1,4-quinones; nucleophilic additions;

D O I：

10.1055/s-2004-822887

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compounds 6 were prepared by a one-step procedure from 1,4-benzoquinone (1) and pyrimidine-2,4,6-triamines 2 via an extension of the Nenitzescu reaction. Formation of 9H-pyrimido[4,5-b]indoles 6 can be calculated by C-13 NMR values of C-5 of the pyrimidine-2,4,6-triamines 2.

引用

页码：1039 / 1043

页数：5

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