Reactive oxygen species: Destroyers or messengers?

被引：257

作者：

Bartosz, Grzegorz ^{[1
,2
]}

机构：

[1] Univ Lodz, Dept Mol Biophys, PL-90237 Lodz, Poland

[2] Univ Rzeszow, Dept Biochem & Cell Biol, Rzeszow, Poland

来源：

BIOCHEMICAL PHARMACOLOGY | 2009年 / 77卷 / 08期

关键词：

NADPH oxidase; Oxidative stress; Protein tyrosine phosphatases; Reactive oxygen species; Signaling; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; NADPH OXIDASE; CELL-PROLIFERATION; REDOX REGULATION; NAD(P)H OXIDASE; NOX ENZYMES; ACTIVATION; RECEPTOR; SUPEROXIDE;

D O I：

10.1016/j.bcp.2008.11.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Abundant evidence leaves no doubt that reactive oxygen species (ROS) are not only inevitable by-products of oxygen metabolism but also play a role in cellular signaling. ROS are produced by a family of NADPH oxidases for signaling purposes and mediate or augment the effects of insulin, growth factors, cytokines and G-protein-coupled receptors. Disturbances of ROS signaling leading to overproduction of these intermediates inflict oxidative damage of cell components in the course of various diseases. Restoration of proper ROS signaling, especially inhibition of cellular sources of ROS, may thus provide new ways of therapy. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1303 / 1315

页数：13

共 76 条

[71] Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4 [J].

Wendt, MC ;

Daiber, A ;

Kleschyov, AL ;

Mülsch, A ;

Sydow, K ;

Schulz, E ;

Chen, K ;

Keaney, JF ;

Lassègue, B ;

Walter, U ;

Griendling, KK ;

Münzel, T .

FREE RADICAL BIOLOGY AND MEDICINE, 2005, 39 (03) :381-391

[72] Protein carbonylation as a novel mechanism in redox signaling [J].

Wong, Chi Ming ;

Cheema, Amrita K. ;

Zhang, Lihua ;

Suzuki, Yuichiro J. .

CIRCULATION RESEARCH, 2008, 102 (03) :310-318

[73] Tumor necrosis factor-α generates reactive oxygen species via a cytosolic phospholipase A2-linked cascade [J].

Woo, CH ;

Eom, YW ;

Yoo, MH ;

You, HJ ;

Han, HJ ;

Song, WK ;

Yoo, YJ ;

Chun, JS ;

Kim, JH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (41) :32357-32362

[74] Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling [J].

Wood, ZA ;

Poole, LB ;

Karplus, PA .

SCIENCE, 2003, 300 (5619) :650-653

[75] Mechanisms of disease: advanced glycation end-products and their receptor in inflammation and diabetes complications [J].

Yan, Shi Fang ;

Ramasamy, Ravichandran ;

Schmidt, Ann Marie .

NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM, 2008, 4 (05) :285-293

[76] Catalase binds GRB2 in tumor cells when stimulated with serum or ligands for integrin receptors [J].

Yano, S ;

Arroyo, N ;

Yano, N .

FREE RADICAL BIOLOGY AND MEDICINE, 2004, 36 (12) :1542-1554

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