Understanding and testing risk mechanisms for mental disorders

被引：49

作者：

Rutter, Michael ^{[1
]}

机构：

[1] Inst Psychiat, SGDP Ctr, London SE5 8AF, England

来源：

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY | 2009年 / 50卷 / 1-2期

关键词：

Mediation; moderation; genetic vs; environmental mediation; natural experiments; causal inferences; ASSOCIATION; ENVIRONMENT; POLYMORPHISM; PSYCHOSIS; CANNABIS; ONSET; GENE; AGE;

D O I：

10.1111/j.1469-7610.2008.01976.x

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Over the past 50 years there has been a virtual revolution in thinking about risk mechanisms. The key areas of challenge and opportunity include: identification of environmental causes; use of natural experiments; gene-environment interaction; testing for mediation; developmental moderation; biological programming; and developmental perturbations.

引用

收藏

页码：44 / 52

页数：9

相关论文

共 48 条

[1]

[Anonymous], 2006, GENES BEHAV

[2]

[Anonymous], 2007, ID ENV CAUS DIS SHOU

[3] Causal association between cannabis and psychosis: examination of the evidence [J].

Arseneault, L ;

Cannon, M ;

Witton, J ;

Murray, RM .

BRITISH JOURNAL OF PSYCHIATRY, 2004, 184 :110-117

[4] THE MODERATOR MEDIATOR VARIABLE DISTINCTION IN SOCIAL PSYCHOLOGICAL-RESEARCH - CONCEPTUAL, STRATEGIC, AND STATISTICAL CONSIDERATIONS [J].

BARON, RM ;

KENNY, DA .

JOURNAL OF PERSONALITY AND SOCIAL PSYCHOLOGY, 1986, 51 (06) :1173-1182

[5] Developmental plasticity and human health [J].

Bateson, P ;

Barker, D ;

Clutton-Brock, T ;

Deb, D ;

D'Udine, B ;

Foley, RA ;

Gluckman, P ;

Godfrey, K ;

Kirkwood, T ;

Lahr, MM ;

McNamara, J ;

Metcalfe, NB ;

Monaghan, P ;

Spencer, HG ;

Sultan, SE .

NATURE, 2004, 430 (6998) :419-421

[6] A REINTERPRETATION OF DIRECTION OF EFFECTS IN STUDIES OF SOCIALIZATION [J].

BELL, RQ .

PSYCHOLOGICAL REVIEW, 1968, 75 (02) :81-&

[7]

Bowlby J., 1982, ATTACHMENT LOSS VOL, V1

[8]

Bretherton I., 2005, Attachment from infancy to adulthood: The major longitudinal studies, P13

[9] Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene X environment interaction [J].

Caspi, A ;

Moffitt, TE ;

Cannon, M ;

McClay, J ;

Murray, R ;

Harrington, H ;

Taylor, A ;

Arseneault, L ;

Williams, B ;

Braithwaite, A ;

Poulton, R ;

Craig, IW .

BIOLOGICAL PSYCHIATRY, 2005, 57 (10) :1117-1127

[10] IT TAKES 2 TO REPLICATE - A MEDIATIONAL MODEL FOR THE IMPACT OF PARENTS STRESS ON ADOLESCENT ADJUSTMENT [J].

CONGER, RD ;

PATTERSON, GR ;

GE, XJ .

CHILD DEVELOPMENT, 1995, 66 (01) :80-97

← 1 2 3 4 5 →