Multivalent glycosylated nanoparticles for studying carbohydrate-protein interactions

被引：47

作者：

Adak, Avijit K. ^{[1
]}

Lin, Hong-Jyune ^{[1
]}

Lin, Chun-Cheng ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 30期

关键词：

ENCAPSULATED GOLD NANOPARTICLES; MAGNETIC GLYCO-NANOPARTICLES; SEMICONDUCTOR QUANTUM DOTS; DRUG-DELIVERY; IRON-OXIDE; COLORIMETRIC DETECTION; QUANTITATIVE-ANALYSIS; GLYCONANOPARTICLES; LECTIN; RECOGNITION;

D O I：

10.1039/c4ob00827h

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

Carbohydrates are essential mediators of many important extracellular binding events. Multivalent effects are often required for these binding interactions that are generally weak. Biologically significant carbohydrate-modified nanomaterials are an appealing model system for a systematic investigation of multivalent binding effects. This review seeks to highlight recent striking examples of multivalent glycosylated nanomaterials concentrating on carbohydrate-protein interactions. The specific aim is to provide an overview of various aspects of glyco-nanoparticles in binding assays, targeted therapy, molecular imaging, enzyme activity assay, and bacterium detection.

引用

收藏

页码：5563 / 5573

页数：11

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