Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots

被引：247

作者：

Choi, Hak Soo ^{[1
]}

Ipe, Binil Itty ^{[3
]}

Misra, Preeti ^{[1
]}

Lee, Jeong Heon ^{[1
]}

Bawendi, Moungi G. ^{[3
]}

Frangioni, John V. ^{[1
,2
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA

[2] Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA

[3] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

NANO LETTERS | 2009年 / 9卷 / 06期

关键词：

IN-VIVO BIODISTRIBUTION; MOUSE-TUMOR MODELS; NANOPARTICLES; CANCER; THERAPY; SIZE; CLEARANCE; PEPTIDE; LIGHT; MICE;

D O I：

10.1021/nl900872r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body.

引用

页码：2354 / 2359

页数：6

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