Design and Synthesis of Fast-Degrading Poly(anhydride-esters)

被引：36

作者：

Carbone, Ashley L. ^{[1
]}

Uhrich, Kathryn E. ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2009年 / 30卷 / 12期

基金：

美国国家卫生研究院;

关键词：

hydrolytic degradation; hydrophilic polymers; poly(anhydride-ester); polyanhydride; polymerization; synthesis; SALICYLATE-BASED POLY(ANHYDRIDE-ESTERS); IN-VITRO; RELEASE; DEGRADATION; POLYMERS; POLYANHYDRIDES; MECHANISMS; BIOFILM;

D O I：

10.1002/marc.200900029

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

Fast-degrading, salicylate-based poly (anhydride-esters) were designed to degrade and release the active component, salicylic acid (SA), within 1 week. The polymer degradation was enhanced by using shorter or oxygen-containing aliphatic chains. A copolymer of diglycolic acid was also made with a salicylate-based diacid for comparison of polymer properties, including SA release. Both methods resulted in polyanhydrides with molecular weights ranging from 14 500 to 27 800 Da and displayed glass transition temperatures near physiological conditions, namely 33-40 degrees C. The homo- and copolymers completely degraded within one week releasing the chemically incorporated SA.

引用

页码：1021 / 1026

页数：6

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