Endosomal proteases and antigen processing

被引:42
作者
Fineschi, B [1 ]
Miller, J [1 ]
机构
[1] UNIV CHICAGO,COMM CELL PHYSIOL,CHICAGO,IL 60637
关键词
D O I
10.1016/S0968-0004(97)01116-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
T cells are activated by fragments of antigenic proteins bound to major histocompatibility compatibility complex (MHC) molecules and displayed on the cell surface. MHC class II proteins scavenge processed protein antigens from within endosomal compartments. The antigenic peptides are generated within these and other intracellular compartments using the array of proteolytic enzymes normally involved in terminal protein degradation. Antigen-presenting cells use different mechanisms to exploit and control the activity of these enzymes so as to ensure the generation of a wide variety of peptides, while preventing the destruction of antigenic epitopes by excessive proteolysis.
引用
收藏
页码:377 / 382
页数:6
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