Regional brain volume change over the life-time course of schizophrenia

The concept that schizophrenia has its antecedents in neurodevelopment has long been debated and has been at the forefront of research on this disorder over the last decade. However new recent evidence from controlled longitudinal studies indicates that some of the structural brain anomalies observed in schizophrenia may continue to progress sporadically after the onset of clinical illness. The studies vary in cohort composition, stage of illness studied, duration of follow-up interval, and specific brain regions with findings. Nevertheless, the findings as a whole suggest that the brain changes in size throughout the lifespan of an individual and to a greater extent in schizophrenia. While the detected abnormalities could be explained by various technical artifacts, or physiological epi-phenomena, that they result from an ongoing neurochemical, physiological or morphological process characteristic of the underlying basis for the disorder is an intriguing possibility that lends itself to possible future intervention. (C) 1999 Elsevier Science Ltd. All rights reserved.