Role of Toll-like receptor 4 in the initiation and progression of atherosclerotic disease

被引：150

作者：

Pasterkamp, G

van Keulen, JK

de Kleijn, DPV

机构：

[1] Univ Med Ctr G02 523, Expt Cardiol Lab, NL-3584 CX Utrecht, Netherlands

[2] Interuniv Cardiol Inst Netherlands, Dept Cardiol, Utrecht, Netherlands

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 34卷 / 05期

关键词：

arteriosclerosis; atherosclerosis; inflammation; innate immunity; plaque vulnerability; Toll-like receptor 4;

D O I：

10.1111/j.1365-2362.2004.01338.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The family of Toll-like receptors (TLRs) initiates an innate immune response after recognition of pathogen-associated molecular patterns (PAMPs). Evidence is accumulating that TLRs, and particularly TLR4, are important players in the initiation and progression of atherosclerotic disease. Not only exogenous ligands but also endogenous ligands that are expressed during arterial injury are recognized by TLR4. Mouse knockout studies and epidemiological studies of human TLR4 polymorphisms have demonstrated that the TLR4 might play a role in the initiation and progression of atherosclerosis. This review will summarize the latest progression in research on the role of TLR4 in arterial occlusive disease In addition, the potential of intervention in TLR4 signalling to influence progression of atherosclerotic disease is discussed.

引用

收藏

页码：328 / 334

页数：7

相关论文

共 74 条

[11] Protective role of phospholipid oxidation products in endotoxin-induced tissue damage [J].

Bochkov, VN ;

Kadl, A ;

Huber, J ;

Gruber, F ;

Binder, BR ;

Leitinger, N .

NATURE, 2002, 419 (6902) :77-81

[12] Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events [J].

Boekholdt, SM ;

Agema, WRP ;

Peters, RJG ;

Zwinderman, AH ;

van der Wall, EE ;

Reitsma, PH ;

Kastelein, JJP ;

Jukema, JW .

CIRCULATION, 2003, 107 (19) :2416-2421

[13] Chlamydial heat shock protein 60 activates macrophages and endothelial cells through toll-like receptor 4 and MD2 in a MyD88-dependent pathway [J].

Bulut, Y ;

Faure, E ;

Thomas, L ;

Karahashi, H ;

Michelsen, KS ;

Equils, O ;

Morrison, SG ;

Morrison, RP ;

Arditi, M .

JOURNAL OF IMMUNOLOGY, 2002, 168 (03) :1435-1440

[14] TRANSCRIPTIONAL REGULATION OF ENDOTHELIAL-CELL ADHESION MOLECULES - NF-KAPPA-B AND CYTOKINE-INDUCIBLE ENHANCERS [J].

COLLINS, T ;

READ, MA ;

NEISH, AS ;

WHITLEY, MZ ;

THANOS, D ;

MANIATIS, T .

FASEB JOURNAL, 1995, 9 (10) :899-909

[15]

Cornford PA, 2000, CANCER RES, V60, P7099

[16]

DIRKS SH, 2002, J ENDOTOXIN RES, V7, P335

[17] Expression of toll-like receptors in human atherosclerotic lesions - A possible pathway for plaque activation [J].

Edfeldt, K ;

Swedenborg, J ;

Hansson, GK ;

Yan, ZQ .

CIRCULATION, 2002, 105 (10) :1158-1161

[18] Bacterial lipopolysaccharide activates NF-κB through Toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells -: Differential expression of TLR-4 and TLR-2 in endothelial cells [J].

Faure, E ;

Equils, O ;

Sieling, PA ;

Thomas, L ;

Zhang, FX ;

Kirschning, CJ ;

Polentarutti, N ;

Muzio, M ;

Arditi, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (15) :11058-11063

[19] Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor α from murine macrophages [J].

Gao, BC ;

Tsan, MF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (25) :22523-22529

[20] Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor a release by murine macrophages [J].

Gao, BC ;

Tsan, MF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (01) :174-179

← 1 2 3 4 5 6 7 8 →