A pilot study on the determination of perfluorooctanesulfonate and other perfluorinated compounds in blood of Canadians

被引：98

作者：

Kubwabo, C ^{[1
]}

Vais, N ^{[1
]}

Benoit, FM ^{[1
]}

机构：

[1] Hlth Canada, Safe Environm Programme, Div Chem Res, Ctr Environm Hlth, Ottawa, ON K1A 0L2, Canada

来源：

JOURNAL OF ENVIRONMENTAL MONITORING | 2004年 / 6卷 / 06期

关键词：

D O I：

10.1039/b314085g

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A pilot study was conducted to provide preliminary data on the concentrations of perfluorooctanesulfonate (PFOS), perfluorooctanoic acid (PFOA) and perfluorooctanesulfonamide (PFOSA) in the blood of Canadians. A set of 56 human serum samples was collected from non-occupationally exposed Canadians and analyzed by microbore HPLC-negative ion electrospray tandem mass spectrometry. PFOS was the main component of perfluorinated organic compounds (PFCs) and was detected in all 56 blood specimens at an average concentration of 28.8 ng mL(-1) and a range from 3.7 to 65.1 ng mL(-1). The concentration of PFOA was an order of magnitude lower than that of PFOS and was found only in 16 samples (29%) at concentrations above the limit of quantification (LOQ). PFOSA was not detected at levels above the method detection limit (MDL) in any of the samples. The levels of PFCs observed in the sample group of non-occupationally exposed humans in Canada were similar to the levels reported in a previous US study with a similar sample pool size. Two distinct PFOS isomers in human serum were identified by accurate mass determination.

引用

页码：540 / 545

页数：6

共 26 条

[1] Perfluorooctanoate, perflourooctanesulfonate, and N-ethyl perfluorooctanesulfonamido ethanol;: peroxisome proliferation and mitochondrial biogenesis [J].

Berthiaume, J ;

Wallace, KB .

TOXICOLOGY LETTERS, 2002, 129 (1-2) :23-32

[2]

CASE MT, 2001, TOXICOLOGIST, V60, P1055

[3] Global distribution of perfluorooctane sulfonate in wildlife [J].

Giesy, JP ;

Kannan, K .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2001, 35 (07) :1339-1342

[4] Perfluorochemical surfactants in the environment [J].

Giesy, JP ;

Kannan, K .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2002, 36 (07) :146A-152A

[5]

Gilliland FD, 1996, AM J IND MED, V29, P560

[6] MORTALITY AMONG EMPLOYEES OF A PERFLUOROOCTANOIC ACID PRODUCTION PLANT [J].

GILLILAND, FD ;

MANDEL, JS .

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 1993, 35 (09) :950-954

[7] Compound-specific, quantitative characterization of organic: Fluorochemicals in biological matrices [J].

Hansen, KJ ;

Clemen, LA ;

Ellefson, ME ;

Johnson, HO .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2001, 35 (04) :766-770

[8] Perfluorooctane sulfonate in fish-eating water birds including bald eagles and albatrosses [J].

Kannan, K ;

Franson, JC ;

Bowerman, WW ;

Hansen, KJ ;

Jones, JD ;

Giesy, JP .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2001, 35 (15) :3065-3070

[9] Accumulation of perfluorooctane sulfonate in marine mammals [J].

Kannan, K ;

Koistinen, J ;

Beckmen, K ;

Evans, T ;

Gorzelany, JF ;

Hansen, KJ ;

Jones, PD ;

Helle, E ;

Nyman, M ;

Giesy, JP .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2001, 35 (08) :1593-1598

[10] Perfluorooctane sulfonate in oysters, Crassostrea virginica, from the Gulf of Mexico and the Chesapeake Bay, USA [J].

Kannan, K ;

Hansen, KJ ;

Wade, TL ;

Giesy, JP .

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2002, 42 (03) :313-318

← 1 2 3 →