Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), for the potential treatment of onychomycosis

被引：264

作者：

Baker, Stephen J. ^{[1
]}

Zhang, Yong-Kang ^{[1
]}

Akama, Tsutomu ^{[1
]}

Lau, Agnes ^{[1
]}

Zhou, Huchen ^{[1
]}

Hernandez, Vincent ^{[1
]}

Mao, Weimin ^{[1
]}

Alley, M. R. K. ^{[1
]}

Sanders, Virginia ^{[1
]}

Plattner, Jacob J. ^{[1
]}

机构：

[1] Anacor Pharmaceut Inc, Palo Alto, CA 94303 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 49卷 / 15期

关键词：

D O I：

10.1021/jm0603724

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), which is currently in clinical trials for onychomycosis topical treatment.

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收藏

页码：4447 / 4450

页数：4

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