Leptin: linking adipocyte metabolism with cardiovascular and autoimmune diseases

被引：83

作者：

Peelman, F

Waelput, W

Iserentant, H

Lavens, D

Eyckerman, S

Zabeau, L

Tavernier, J

机构：

[1] Ghent Univ VIB, Dept Med Prot Res, Fac Med & Hlth Sci, B-9000 Ghent, Belgium

[2] Univ Ghent, Fac Med & Hlth Sci, Dept Pathol, B-9000 Ghent, Belgium

来源：

PROGRESS IN LIPID RESEARCH | 2004年 / 43卷 / 04期

关键词：

D O I：

10.1016/j.plipres.2004.03.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leptin was originally discovered as an adipocyte-derived hormone involved in the central control of body weight and energy homeostasis. It is now clear that leptin is a pleiotropic cytokine, with activities on many peripheral cell types. These findings may help explain the surprising role of leptin in pathophysiological processes. Recent evidence suggests that leptin contributes to atherosclerosis and to the increased risk of cardiovascular disease in obese people. Leptin also appears to be involved in T-cell-dependent immunity and possibly in the development and maintenance of certain autoimmune diseases. Here, we review the role of leptin in cardiovascular and autoimmune diseases, and also briefly address the potential therapeutic use of leptin antagonists. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：283 / 301

页数：19

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