Conserved response regulator CtrA and IHF binding sites in the α-proteobacteria Caulobacter crescentus and Rickettsia prowazekii chromosomal replication origins

被引：35

作者：

Brassinga, AKC

Siam, R

McSween, W

Winkler, H

Wood, D

Marczynski, GT

机构：

[1] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ H3A 2B4, Canada

[2] Dalhousie Univ, Dept Microbiol & Immunol, Halifax, NS B3H 4H7, Canada

[3] Salk Inst Biol Studies, Mol & Cellular Biol Lab, La Jolla, CA 92037 USA

[4] Univ S Alabama, Coll Med, Dept Microbiol & Immunol, Mobile, AL 36688 USA

来源：

JOURNAL OF BACTERIOLOGY | 2002年 / 184卷 / 20期

关键词：

D O I：

10.1128/JB.184.20.5789-5799.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

CzcR is the Rickettsia prowazekii homolog of the Caulobacter crescentus global response regulator CtrA. CzcR expression partially compensates for developmental defects in ctrA mutant C. crescentus cells, and CzcR binds to all five CtrA binding sites in the C. crescentus replication origin. Conversely, CtrA binds to five similar sites in the putative R. prowazekii replication origin (oriRp). Also, Escherichia coli IHF protein binds over a central CtrA binding site in oriRp. Therefore, CtrA and IHF regulatory proteins have similar binding patterns in both replication origins, and we propose that CzcR is a global cell cycle regulator in R. prowazekii.

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收藏

页码：5789 / 5799

页数：11

相关论文

共 36 条

[1] Bioenergetics of the obligate intracellular parasite Rickettsia prowazekii [J].

Andersson, SGE .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1998, 1365 (1-2) :105-111

[2] The genome sequence of Rickettsia prowazekii and the origin of mitochondria [J].

Andersson, SGE ;

Zomorodipour, A ;

Andersson, JO ;

Sicheritz-Pontén, T ;

Alsmark, UCM ;

Podowski, RM ;

Näslund, AK ;

Eriksson, AS ;

Winkler, HH ;

Kurland, CG .

NATURE, 1998, 396 (6707) :133-140

[3] A homolog of the CtrA cell cycle regulator is present and essential in Sinorhizobium meliloti [J].

Barnett, MJ ;

Hung, DY ;

Reisenauer, A ;

Shapiro, L ;

Long, SR .

JOURNAL OF BACTERIOLOGY, 2001, 183 (10) :3204-3210

[4] Limiting DNA replication to once and only once [J].

Boye, E ;

Lobner-Olesen, A ;

Skarstad, K .

EMBO REPORTS, 2000, 1 (06) :479-483

[5] A MODEL FOR INITIATION AT ORIGINS OF DNA-REPLICATION [J].

BRAMHILL, D ;

KORNBERG, A .

CELL, 1988, 54 (07) :915-918

[6] Conserved gene cluster at replication origins of the α-proteobacteria Caulobacter crescentus and Rickettsia prowazekii [J].

Brassinga, AKC ;

Siam, R ;

Marczynski, GT .

JOURNAL OF BACTERIOLOGY, 2001, 183 (05) :1824-1829

[7] Replication intermediate analysis confirms that chromosomal replication origin initiates from an unusual intergenic region in Caulobacter crescentus [J].

Brassinga, AKC ;

Marczynski, GT .

NUCLEIC ACIDS RESEARCH, 2001, 29 (21) :4441-4451

[8] THE EXPRESSION OF ASYMMETRY DURING CAULOBACTER CELL-DIFFERENTIATION [J].

BRUN, YV ;

MARCZYNSKI, G ;

SHAPIRO, L .

ANNUAL REVIEW OF BIOCHEMISTRY, 1994, 63 :419-450

[9] Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021 [J].

Capela, D ;

Barloy-Hubler, F ;

Gouzy, J ;

Bothe, G ;

Ampe, F ;

Batut, J ;

Boistard, P ;

Becker, A ;

Boutry, M ;

Cadieu, E ;

Dréano, S ;

Gloux, S ;

Godrie, T ;

Goffeau, A ;

Kahn, D ;

Kiss, E ;

Lelaure, V ;

Masuy, D ;

Pohl, T ;

Portetelle, D ;

Pühler, A ;

Purnelle, B ;

Ramsperger, U ;

Renard, C ;

Thébault, P ;

Vandenbol, M ;

Weidner, S ;

Galibert, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (17) :9877-9882

[10] Feedback control of a master bacterial cell-cycle regulator [J].

Domian, IJ ;

Reisenauer, A ;

Shapiro, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) :6648-6653

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