Antibodies against oxidized LDL and apolipoprotein E polymorphism in demented patients

被引：2

作者：

Bednarska-Makaruk, Malgorzata ^{[1
]}

Rodo, Maria ^{[1
]}

Graban, Alla ^{[2
]}

Lojkowska, Wanda ^{[2
]}

Bochynska, Anna ^{[2
]}

Ryglewicz, Danuta ^{[2
]}

Wehr, Hanna ^{[1
]}

机构：

[1] Inst Psychiat & Neurol, Dept Genet, PL-02957 Warsaw, Poland

[2] Inst Psychiat & Neurol, Dept Neurol 1, Warsaw, Poland

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2009年 / 283卷 / 1-2期

关键词：

Anti-oxLDL antibodies; Apo E polymorphism; DENSITY; AUTOANTIBODIES; B-100;

D O I：

10.1016/j.jns.2009.02.345

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

In serum of 114 patients with dementia and of 102 controls the level of IG class immunoglobulins directed against oxidized LDL and lipids were determined. In isolated DNA apolipoprotein E gene (APOE) polymorphism was identified. In some individuals very high levels of the antibodies were observed. exceeding the 90 percentile in the investigated group. The prevalence of very high anti-ox LDL antibodies level was significantly more frequent in the carriers of epsilon 2 allele and less frequent in the carriers of epsilon 4 allele. (C) 2009 Elsevier B.V. All rights reserved

引用

页码：137 / 138

页数：2

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