NAD+ as a Signaling Molecule Modulating Metabolism

被引：78

作者：

Canto, C. ^{[1
]}

Auwerx, J. ^{[2
]}

机构：

[1] Nestle Inst Hlth Sci, CH-1015 Lausanne, Switzerland

[2] Ecole Polytech Fed Lausanne, CH-1015 Lausanne, Switzerland

来源：

METABOLISM AND DISEASE | 2011年 / 76卷

基金：

瑞士国家科学基金会; 欧洲研究理事会; 美国国家卫生研究院;

关键词：

NICOTINAMIDE ADENINE-DINUCLEOTIDE; POLY(ADP-RIBOSE) POLYMERASE; LIFE-SPAN; SACCHAROMYCES-CEREVISIAE; MITOCHONDRIAL-FUNCTION; CALORIE RESTRICTION; HISTONE DEACETYLASE; ACTIVATING SIRT1; GAMMA-RADIATION; RELEASE NIACIN;

D O I：

10.1101/sqb.2012.76.010439

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The ability of NAD(+) to act as a metabolic cofactor and as a rate-limiting cosubstrate for many enzymes, particularly the sirtuins, has led to the identification of a pivotal role of NAD(+) levels in the control of whole-body metabolic homeostasis. Bioavailability and compartmentalization of NAD(+) have become highly relevant issues that we need to understand in order to elucidate how NAD(+) acts both as a readout of the metabolic milieu and as an effector triggering appropriate cellular adaptations.

引用

收藏

页码：291 / 298

页数：8

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