Synthesis of novel heterocycles through reaction of indolin-2-one derivatives with active methylene and amino reagents

被引：4

作者：

AbdelLatif, FF

Ahmed, EK

Mekheimer, R

Mashaly, MM

机构：

[1] MENIA UNIV,FAC SCI,DEPT CHEM,MENIA,EGYPT

[2] MANSOURA UNIV,DUMYAT,EGYPT

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1997年 / 20卷 / 05期

关键词：

heterocycles; indolin-2-one; malononitrile; methylene and amino reagents;

D O I：

10.1007/BF02973949

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Several new spiro compounds were synthesized via one-pot ternary condensation of isatin, malononitrile and each of thiobarbituric acid, barbituric acid, 3-methyl-pyrazolin-5-one, 1-phenyl-3-methyl-pyrazolin-5-one, acetylacetone, benzoylacetone, ethyl acetoacetate, phenacyl cyanide or ethyl-cyanoacetate dimer. Structures and reaction mechanisms were reported and supported via a second synthetic route.

引用

页码：507 / 509

页数：3

共 9 条

[1]

THE SYNTHESIS OF HETEROCYCLES FROM INDOLIN-2-ONE DERIVATIVES AND ACTIVE METHYLENE REAGENTS [J].