Microbiology - Death of a chaperone

被引：7

作者：

Montecucco, Cesare ^{[1
]}

Molinari, Maurizio

机构：

[1] Univ Padua, Dept Biomed Sci, I-35121 Padua, Italy

[2] Inst Res Biomed, CH-6500 Bellinzona, Switzerland

来源：

NATURE | 2006年 / 443卷 / 7111期

关键词：

D O I：

10.1038/443511a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To help their growth and spread, bacteria rely on virulence factors, many of which are toxic. One such factor is highly potent, as it attacks a key protein that 'chaperones' other proteins through their synthesis.

引用

页码：511 / 512

页数：2

共 9 条

[1] Anthrax toxins: a paradigm of bacterial immune suppression [J].

Baldari, Cosima T. ;

Tonello, Fiorella ;

Paccani, Silvia Rossi ;

Montecucco, Cesare .

TRENDS IN IMMUNOLOGY, 2006, 27 (09) :434-440

[2] Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment [J].

Dong, DZ ;

Ko, BC ;

Baumeister, P ;

Swenson, S ;

Costa, F ;

Markland, F ;

Stiles, C ;

Patterson, JB ;

Bates, SE ;

Lee, AS .

CANCER RESEARCH, 2005, 65 (13) :5785-5791

[3]

Hendershot LM, 2004, MT SINAI J MED, V71, P289

[4] GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development [J].

Luo, Shengzhan ;

Mao, Changhui ;

Lee, Brenda ;

Lee, Amy S. .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (15) :5688-5697

[5] AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP [J].

Paton, Adrienne W. ;

Beddoe, Travis ;

Thorpe, Cheleste M. ;

Whisstock, James C. ;

Wilce, Matthew C. J. ;

Rossjohn, Jamie ;

Talbot, Ursula M. ;

Paton, James C. .

NATURE, 2006, 443 (7111) :548-552

[6] A new family of potent AB5 cytotoxins produced by Shiga toxigenic Escherichia coli [J].

Paton, AW ;

Srimanote, P ;

Talbot, UM ;

Wang, H ;

Paton, JC .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (01) :35-46

[7] Tetanus and botulinum neurotoxins: turning bad guys into good by research [J].

Rossetto, O ;

Seveso, M ;

Caccin, P ;

Schiavo, G ;

Montecucco, C .

TOXICON, 2001, 39 (01) :27-41

[8] Shiga toxins [J].

Sandvig, K .

TOXICON, 2001, 39 (11) :1629-1635

[9] Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome [J].

Tarr, PI ;

Gordon, CA ;

Chandler, WL .

LANCET, 2005, 365 (9464) :1073-1086

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