Ubiquitination: RING for destruction?

被引：440

作者：

Freemont, PS ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Mol Struct & Funct Lab, London WC2A 3PX, England

来源：

CURRENT BIOLOGY | 2000年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0960-9822(00)00287-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ubiquitination targets proteins for degradation and is a potent regulator of cellular protein function. Recent results implicate the RING finger domain in specific ubiquitination events; it is possible that all RING proteins act as E3 ubiquitin protein ligases, with implications for a variety of biological areas.

引用

页码：R84 / R87

页数：4

共 20 条

[1] A RING-H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae
Bordallo, J
Wolf, DH
[J]. FEBS LETTERS, 1999, 448 (2-3) : 244 - 248
[2] Duprez E, 1999, J CELL SCI, V112, P381
[3] Components of an SCE ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle
Freed, E
Lacey, KR
Huie, P
Lyapina, SA
Deshaies, RJ
Stearns, T
Jackson, PK
[J]. GENES & DEVELOPMENT, 1999, 13 (17) : 2242 - 2257
[4] Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
Honda, R
Yasuda, H
[J]. EMBO JOURNAL, 1999, 18 (01) : 22 - 27
[5] Hu G, 1999, MOL CELL BIOL, V19, P724
[6] BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression
Jensen, DE
Proctor, M
Marquis, ST
Gardner, HP
Ha, SI
Chodosh, LA
Ishov, AM
Tommerup, N
Vissing, H
Sekido, Y
Minna, J
Borodovsky, A
Schultz, DC
Wilkinson, KD
Maul, GG
Barlev, N
Berger, SL
Prendergast, GC
Rauscher, FJ
[J]. ONCOGENE, 1998, 16 (09) : 1097 - 1112
[7] The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
Joazeiro, CAP
Wing, SS
Huang, HK
Leverson, JD
Hunter, T
Liu, YC
[J]. SCIENCE, 1999, 286 (5438) : 309 - 312
[8] Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
Kamura, T
Koepp, DM
Conrad, MN
Skowyra, D
Moreland, RJ
Iliopoulos, O
Lane, WS
Kaelin, WG
Elledge, SJ
Conaway, RC
Harper, JW
Conway, JW
[J]. SCIENCE, 1999, 284 (5414) : 657 - 661
[9] Herpes simplex virus type 1 immediate-early protein Vmw110 inhibits progression of cells through mitosis and from G1 into S phase of the cell cycle
Lomonte, P
Everett, RD
[J]. JOURNAL OF VIROLOGY, 1999, 73 (11) : 9456 - 9467
[10] RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
Lorick, KL
Jensen, JP
Fang, SY
Ong, AM
Hatakeyama, S
Weissman, AM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) : 11364 - 11369

← 1 2 →