REV-ving up the clock

被引：5

作者：

Alvarez, JD ^{[1
]}

Sehgal, A

机构：

[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Dept Neurosci, Philadelphia, PA 19104 USA

来源：

DEVELOPMENTAL CELL | 2002年 / 3卷 / 02期

关键词：

D O I：

10.1016/S1534-5807(02)00225-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Circadian rhythms are generated by a transcription/translation feedback loop consisting of two limbs, one positive and one negative. The nuclear orphan receptor, REV-ERBα, is identified as a molecular link coupling these two limbs.

引用

页码：150 / 152

页数：3

共 10 条

[1] Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus [J].

Akhtar, RA ;

Reddy, AB ;

Maywood, ES ;

Clayton, JD ;

King, VM ;

Smith, AG ;

Gant, TW ;

Hastings, MH ;

Kyriacou, CP .

CURRENT BIOLOGY, 2002, 12 (07) :540-550

[2] Resetting of circadian time peripheral tissues by glucocorticoid signaling [J].

Balsalobre, A ;

Brown, SA ;

Marcacci, L ;

Tronche, F ;

Kellendonk, C ;

Reichardt, HM ;

Schütz, G ;

Schibler, U .

SCIENCE, 2000, 289 (5488) :2344-2347

[3] A serum shock induces circadian gene expression in mammalian tissue culture cells [J].

Balsalobre, A ;

Damiola, F ;

Schibler, U .

CELL, 1998, 93 (06) :929-937

[4] Combinatorial control of gene expression by nuclear receptors and coregulators [J].

McKenna, NJ ;

O'Malley, BW .

CELL, 2002, 108 (04) :465-474

[5] Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: A humoral mechanism to reset a peripheral clock [J].

McNamara, P ;

Seo, SB ;

Rudic, RD ;

Sehgal, A ;

Chakravarti, D ;

FitzGerald, GA .

CELL, 2001, 105 (07) :877-889

[6] Coordinated transcription of key pathways in the mouse by the circadian clock [J].

Panda, S ;

Antoch, MP ;

Miller, BH ;

Su, AI ;

Schook, AB ;

Straume, M ;

Schultz, PG ;

Kay, SA ;

Takahashi, JS ;

Hogenesch, JB .

CELL, 2002, 109 (03) :307-320

[7] The orphan nuclear receptor REV-ERBα controls circadian transcription within the positive limb of the mammalian circadian oscillator [J].

Preitner, N ;

Damiola, F ;

Molina, LL ;

Zakany, J ;

Duboule, D ;

Albrecht, U ;

Schibler, U .

CELL, 2002, 110 (02) :251-260

[8] Molecular analysis of mammalian circadian rhythms [J].

Reppert, SM ;

Weaver, DR .

ANNUAL REVIEW OF PHYSIOLOGY, 2001, 63 :647-676

[9] Extensive and divergent circadian gene expression in liver and heart [J].

Storch, KF ;

Lipan, O ;

Leykin, I ;

Viswanathan, N ;

Davis, FC ;

Wong, WH ;

Weitz, CJ .

NATURE, 2002, 417 (6884) :78-83

[10] Role of molecular oscillations in generating behavioral rhythms in Drosophila [J].

Yang, ZH ;

Sehgal, A .

NEURON, 2001, 29 (02) :453-467

← 1 →