Use of 5,5-(Dimethyl)-i-Pr-PHOX as a Practical Equivalent to t-Bu-PHOX in Asymmetric Catalysis

被引：43

作者：

Belanger, Etienne ^{[1
]}

Pouliot, Marie-France ^{[1
]}

Paquin, Jean-Francois ^{[1
]}

机构：

[1] Univ Laval, Canada Res Chair Organ & Med Chem, Dept Chim, Quebec City, PQ G1V 0A6, Canada

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 10期

基金：

加拿大创新基金会; 加拿大自然科学与工程研究理事会;

关键词：

ENANTIOSELECTIVE TOTAL-SYNTHESIS; ALPHA-IMINO ESTERS; PHOSPHINOOXAZOLINE LIGANDS; ALLYLATION REACTION; HECK REACTIONS; ENOL ETHERS; CYCLIZATION; ALKYLATION; COMPLEXES; 5,5-DIMETHYL-4-ISO-PROPYLOXAZOLIDIN-2-ONE;

D O I：

10.1021/ol9005618

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of 5,5(dimethyl)-i-Pr-PHOX as a practical equivalent of t-Bu-PHOX in asymmetric catalysis is reported. This new member of the phosphinooxazoline (PHOX) ligand family behaves similarly in terms of stereoinduction to t-Bu-PHOX with the key advantage of being readily accessible as both enantiomers starting from either (S)- or (R)-valine.

引用

页码：2201 / 2204

页数：4

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