Matrix metalloproteinase-2,-9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension

被引：110

作者：

Derosa, Giuseppe

D'Angelo, Angela

Ciccarelli, Leonardina

Piccinni, Mario N.

Pricolo, Fabio

Salvadeo, Sibilla

Montagna, Lorenza

Gravina, Alessia

Ferrari, Ilaria

Galli, Simona

Paniga, Sonia

Tinelli, Carmine

Cicero, Arrigo F. G.

机构：

[1] Univ Pavia, Dept Internal Med & Therapeut, I-27100 Pavia, Italy

[2] IRCCS Policlin S Matteo, Biometr Unit, Pavia, Italy

[3] Univ Bologna, D Campanacci Dept Clin Med & Appl Biotechnol, G Descovich Atherosclerosis Study Ctr, Bologna, Italy

来源：

ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH | 2006年 / 13卷 / 03期

关键词：

extracellular matrix; hypertension; metalloproteinases; tissue inhibitors of metalloproteinases;

D O I：

10.1080/10623320600780942

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There are conflicting data in the literature regarding the expression pattern of the vascular matrix metalloproteinase (MMP) system and their inhibitors (TIMPs) in human hypertension. The authors hypothesized that MMP-2, MMP-9, and TIMP-1 would be abnormal in hypertension, reflecting alterations in extracellular matrix (ECM) turnover. The authors measured plasma levels and activities of MMP-2, MMP-9, and TIMP-1 in 44 hypertensive patients and 44 controls. MMP-2 levels and activity were significantly higher in hypertensive group (p <.0001). Significant increase was also observed for MMP-9 level and activity (p<.0001) and for TIMP-1 (p<.0001) in hypertensive patients. Plasma levels and activities of MMP-2, MMP-9, and TIMP-1 are increased in hypertensive patients, which may reflect abnormal ECM metabolism.

引用

页码：227 / 231

页数：5

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