C-reactive protein and insulin resistance in non-obese Japanese type 2 diabetic patients

被引:52
作者
Taniguchi, A
Nagasaka, S
Fukushima, M
Sakai, M
Okumura, T
Yoshii, S
Watanabe, T
Ogura, M
Yamadori, N
Nin, K
Kuroe, A
Yamada, Y
Seino, Y
Nakai, Y
机构
[1] Kansai Denryoku Hosp, Div Diabet, Fukushima Ku, Osaka, Osaka 5530003, Japan
[2] Jichi Med Sch, Div Endocrinol & Metab, Minami Kawachi, Tochigi, Japan
[3] Kyoto Univ, Grad Sch Med, Dept Diabet & Clin Nutr, Kyoto, Japan
[4] Nagoya Univ, Sch Hlth Sci, Aichi, Japan
[5] Kyoto Univ, Coll Med Technol, Kyoto 606, Japan
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 2002年 / 51卷 / 12期
关键词
D O I
10.1053/meta.2002.36312
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aim of the present study was to investigate the relationship between C-reactive protein (CRP) and insulin resistance in non-obese Japanese type 2 diabetic patients. A total of 135 non-obese Japanese type 2 diabetic patients (96 men and 39 women, aged 36 to 83 years, with a body mass index [BMI] of 16.2 to 26.8 kg/m2) were studied. BMI, glycosylated hemoglobin (HbA(1c)), fasting concentrations of plasma glucose, serum lipids (triglycerides, low-density lipoprotein [LDL] cholesterol, high-density lipoprotein [HDL] cholesterol, and total cholesterol), CRP, and fibrinogen were measured. LDL cholesterol was calculated using the Friedewald formula. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). Univariate regression analysis showed that CRP value was positively correlated to age (r = 0.218, P = .012), BMI (r = 0.239, P = .006), HOMA-IR (r = 0.397, P < .0001), triglycerides (r = 0.310, P < .005), LDL cholesterol (r = 0.179, P = .038), and fibrinogen (r = 0.371, P < .0001) levels and inversely correlated to HDL cholesterol (r = 0.174, P = .044) level in our diabetic patients. Multiple regression analysis showed that CRP was independently predicted by HOMA-IR (P < .0001, F = 11.6) and fibrinogen (P < .0001, F = 34.2), which explained 23.5% of the variability of CRP in our non-obese Japanese type 2 diabetic patients. These results indicate that insulin resistance and fibrinogen level are independent predictors of CRP in non-obese Japanese type 2 diabetic patients. Copyright 2002, Elsevier Science (USA). All rights reserved.
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收藏
页码:1578 / 1581
页数:4
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