Comparison of ultrasound and electromagnetic field effects on osteoblast growth

被引：80

作者：

Li, JKJ

Lin, JCA

Liu, HC

Sun, JS

Ruaan, RC

Shih, C

Chang, WHS ^{[1
]}

机构：

[1] Chung Yuan Christian Univ, Ctr Nano Bioengn, Dept Biomed Engn, Chungli 32023, Taiwan

[2] Natl Taiwan Univ, Ctr Med, Dept Orthopaed Surg, Taipei 10764, Taiwan

[3] Natl Cent Univ, Dept Chem & Mat Engn, Chungli 32054, Taiwan

[4] Natl Def Med Ctr, Dept Biol & Anat, Taipei, Taiwan

[5] Natl Yang Ming Univ, Inst Rehabil Sci & Technol, Taipei 112, Taiwan

来源：

ULTRASOUND IN MEDICINE AND BIOLOGY | 2006年 / 32卷 / 05期

关键词：

Wistar rat calvaria; mechanism; NO synthase; protein kinase; inositol phosphate pathway; Ca2+ release; stretch activated ion channel; calmodulin; enhanced bone repair;

D O I：

10.1016/j.ultrasmedbio.2006.01.017

中图分类号：

O42 [声学];

学科分类号：

070206 [声学]; 082403 [水声工程];

摘要：

This study compares the mechanisms of ultrasound (US) on osteoblast proliferation with those of pulsed electromagnetic field (PEMF), by different signal transduction pathway inhibitors. The cells were stimulated for 15 min under US or for 2 h under PEMF exposure. Twenty-four h after the beginning of stimulation, the cells were harvested and used for mitochondrial activity test (MTT) analysis. The results showed that there are different transduction pathways for US and PEMF stimulation that lead to an upgrade of osteoblast proliferation, although their pathways all lead to an increase in cytocolic Ca2+ and activation of calmodulin. These findings offer a biochemical mechanism to support the process of ultrasound and PEMF-induced enhanced healing of bone fractures. (E-mail: whchang@cycu.edu.tw) (c) 2006 World Federation for Ultrasound in Medicine & Biology.

引用

页码：769 / 775

页数：7

共 26 条

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