Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass

被引：114

作者：

Bonda, David J. ^{[1
]}

Wang, Xinglong ^{[1
]}

Lee, Hyoung-Gon ^{[1
]}

Smith, Mark A. ^{[1
]}

Perry, George ^{[1
,2
,3
]}

Zhu, Xiongwei ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

[2] Univ Texas San Antonio, UTSA Neurosci Inst, San Antonio, TX USA

[3] Univ Texas San Antonio, Dept Biol, San Antonio, TX USA

来源：

NEUROSCIENCE BULLETIN | 2014年 / 30卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; amyloid-beta; free radicals; mitochondria; mitochondrial dynamics; oxidative stress; ABNORMAL MITOCHONDRIAL DYNAMICS; ACETYL-L-CARNITINE; AMYLOID PRECURSOR PROTEIN; ALPHA-LIPOIC-ACID; LIPID-PEROXIDATION; RNA OXIDATION; OLD RATS; NEUROFIBRILLARY TANGLES; PROMINENT FEATURE; BETA DEPOSITION;

D O I：

10.1007/s12264-013-1424-x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Considerable debate and controversy surround the cause(s) of Alzheimer's disease (AD). To date, several theories have gained notoriety, however none is universally accepted. In this review, we provide evidence for the oxidative stress-induced AD cascade that posits aged mitochondria as the critical origin of neurodegeneration in AD.

引用

页码：243 / 252

页数：10

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