Phenolic Alkaloids as a New Class of Antioxidants in Portulaca oleracea

被引：154

作者：

Yang, Zijuan ^{[1
,2
]}

Liu, Cejia ^{[1
]}

Xiang, Lan ^{[1
]}

Zheng, Yinan ^{[1
,2
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Peoples R China

[2] Jilin Agr Univ, Sch Chinese Mat Med, Changchun 130118, Peoples R China

来源：

PHYTOTHERAPY RESEARCH | 2009年 / 23卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Phenolic alkaloids; Portulaca oleracea; antioxidant activity; PURSLANE; EXTRACTS;

D O I：

10.1002/ptr.2742

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Antioxidant activities of three phenolic alkaloids, i.e., oleracein A (OA), oleracein B (011) and oleracein E (OE), isolated from Portulaca oleracea were determined, based on scavenging activity against 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical and inhibitory effect on hydrogen peroxide-induced lipid peroxidation in rat brain homogenates. The DPPH radical scavenging activities of these phenolic alkaloids were lower than caffeic acid but higher than ascorbic acid and alpha-tocopherol, being in the following order: OB > OA > OE. OE was most potent in preventing formation of malondialdehyde (MDA) with an EC50 value of 73.13 mu M close to that of caffeic acid (72.09 mu M). It was demonstrated that phenolic alkaloids served as a new class of antioxidant agents in this plant. Copyright (C) 2009 John Wiley & Sons, Ltd.

引用

页码：1032 / 1035

页数：4

共 12 条

[1]

Alzheimer's disease and oxidative stress: Implications for novel therapeutic approaches [J].