ROS as a tumour suppressor?

被引：195

作者：

Ramsey, Matthew R. ^{[1
]}

Sharpless, Norman E.

机构：

[1] Univ N Carolina, Sch Med, Dept Med, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Sch Med, Dept Genet, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

NATURE CELL BIOLOGY | 2006年 / 8卷 / 11期

关键词：

D O I：

10.1038/ncb1106-1213

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Senescence is an important mechanism for suppressing mammalian tumours and it may also contribute to aging. A new study suggests that changes in the metabolism of oxygen radicals are important for establishing senescence and blocking cytokinesis to ensure senescent cells never divide again.

引用

收藏

页码：1213 / 1215

页数：3

相关论文

共 15 条

[1]

Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group, 1994, N Engl J Med, V330, P1029, DOI 10.1056/NEJM199404143301501

[2] Reversal of human cellular senescence:: roles of the p53 and p16 pathways [J].

Beauséjour, CM ;

Krtolica, A ;

Galimi, F ;

Narita, M ;

Lowe, SW ;

Yaswen, P ;

Campisi, J .

EMBO JOURNAL, 2003, 22 (16) :4212-4222

[3] Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts [J].

Chen, JH ;

Stoeber, K ;

Kingsbury, S ;

Ozanne, SE ;

Williams, GH ;

Hales, CN .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (47) :49439-49446

[4] p16INK4a can initiate an autonomous senescence program [J].

Dai, CY ;

Enders, GH .

ONCOGENE, 2000, 19 (13) :1613-1622

[5] Reflections on the landmark studies of β-carotene supplementation [J].

Duffield-Lillico, AJ ;

Begg, CB .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2004, 96 (23) :1729-1731

[6] Oxidant signals and oxidative stress [J].

Finkel, T .

CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (02) :247-254

[7] Cellular senescence in naevi and immortalisation in melanoma: a role for p16? [J].

Gray-Schopfer, V. C. ;

Cheong, S. C. ;

Chong, H. ;

Chow, J. ;

Moss, T. ;

Abdel-Malek, Z. A. ;

Marais, R. ;

Wynford-Thomas, D. ;

Bennett, D. C. .

BRITISH JOURNAL OF CANCER, 2006, 95 (04) :496-505

[8] BRAFE600-associated senescence-like cell cycle arrest of human naevi [J].

Michaloglou, C ;

Vredeveld, LCW ;

Soengas, MS ;

Denoyelle, C ;

Kuilman, T ;

van der Horst, CMAM ;

Majoor, DM ;

Shay, JW ;

Mooi, WJ ;

Peeper, DS .

NATURE, 2005, 436 (7051) :720-724

[9] Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence [J].

Narita, M ;

Nunez, S ;

Heard, E ;

Narita, M ;

Lin, AW ;

Hearn, SA ;

Spector, DL ;

Hannon, GJ ;

Lowe, SW .

CELL, 2003, 113 (06) :703-716

[10] Senescence comes of age [J].

Narita, M ;

Lowe, SW .

NATURE MEDICINE, 2005, 11 (09) :920-922