Development of the enteric nervous system and its role in intestinal motility during fetal and early postnatal stages

被引：88

作者：

Burns, Alan J. ^{[2
]}

Roberts, Rachael R. ^{[1
]}

Bornstein, Joel C. ^{[1
]}

Young, Heather M. ^{[1
]}

机构：

[1] Univ Melbourne, Dept Physiol Anat & Cell Biol, Melbourne, Vic 3010, Australia

[2] UCL, Inst Child Hlth, Neural Dev Unit, London, England

来源：

SEMINARS IN PEDIATRIC SURGERY | 2009年 / 18卷 / 04期

关键词：

Neural crest; Hirschsprung's disease; Interstitial cells of Cajal; Motility disorders; Enteric neuron; CREST-DERIVED CELLS; INTERSTITIAL-CELLS; NEURAL-CREST; SMOOTH-MUSCLE; C-KIT; ELECTRICAL RHYTHMICITY; HIRSCHSPRUNGS-DISEASE; GUT MOTILITY; GASTROINTESTINAL-TRACT; COLONIC MOTILITY;

D O I：

10.1053/j.sempedsurg.2009.07.001

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

Motility patterns in the mature intestine require the coordinated interaction of enteric neurons, gastrointestinal smooth muscle, and interstitial cells of Cajal. In Hirschsprung's disease, the aganglionic segment causes functional obstruction, and thus the enteric nervous system (ENS) is essential for gastrointestinal motility after birth. Here we review the development of the ENS. We then focus on motility patterns in the small intestine and colon of fetal mice and larval zebrafish, where recent studies have shown that the first intestinal motility patterns are not neurally mediated. Finally, we review the development of gastrointestinal motility in humans. Crown Copyright (C) 2009 Published by Elsevier Inc. All rights reserved.

引用

页码：196 / 205

页数：10

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