ACE2: from vasopeptidase to SARS virus receptor

被引：450

作者：

Turner, AJ ^{[1
]}

Hiscox, JA ^{[1
]}

Hooper, NM ^{[1
]}

机构：

[1] Univ Leeds, Sch Biochem & Microbiol, Leeds LS2 9JT, W Yorkshire, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2004年 / 25卷 / 06期

关键词：

D O I：

10.1016/j.tips.2004.04.001

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The zinc metallopeptidase angiotensin-converting enzyme 2 (ACE2) is the only known human homologue of the key regulator of blood pressure angiotensin-converting enzyme (ACE). Since its discovery in 2000, ACE2 has been implicated in heart function, hypertension and diabetes, with its effects being mediated, in part, through its ability to convert angiotensin II to angiotensin-(1-7). Unexpectedly, ACE2 also serves as the cellular entry point for the severe acute respiratory syndrome (SARS) virus and the enzyme is therefore a prime target for pharmacological intervention on several disease fronts.

引用

页码：291 / 294

页数：4

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