Elevated endothelin levels are associated with increased placental resistance

被引:24
作者
HarveyWilkes, KB
Nielsen, HC
DAlton, ME
机构
[1] TUFTS UNIV,NEW ENGLAND MED CTR,DEPT PEDIAT,DIV NEWBORN MED,BOSTON,MA 02111
[2] TUFTS UNIV,NEW ENGLAND MED CTR,DEPT PEDIAT,DIV MATERNAL FETAL MED,BOSTON,MA 02111
[3] TUFTS UNIV,NEW ENGLAND MED CTR,FLOATING HOSP CHILDREN,DEPT OBSTET & GYNECOL,BOSTON,MA 02111
关键词
endothelin; fetal growth restriction; umbilical velocimetry; oligohydramnios;
D O I
10.1016/S0002-9378(96)70613-0
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: The purpose of this study was to measure cord blood endothelin-1,2 concentrations in growth-restricted infants with abnormal flow velocity waveforms. STUDY DESIGN: Endothelin-1,2 concentrations were measured by radioimmunoassay in the cord blood of 16 growth-restricted infants with abnormal flow velocity waveforms before delivery, 16 growth-restricted infants with normal flow velocity waveforms before delivery, and 44 appropriately grown infants. Clinical data regarding pregnancy complications and neonatal outcome were collected. RESULTS: The mean endothelin-1,2 concentration in growth-restricted infants with abnormal flow velocity waveforms (50.2 +/- 16.4 pg/ml) was significantly higher than in growth-restricted infants with normal flow velocity waveforms (33.3 +/- 14.2 pg/ml, p < 0.05) or in appropriately grown infants (25.8 +/- 9.7 pg/ml, p < 0.05). Oligohydramnios was also associated with elevated endothelin levels. CONCLUSION: We conclude that endothelin-1,2 concentrations are elevated in growth-restricted infants with abnormal flow velocity waveforms and may play a role in the development of abnormal fetoplacental resistance.
引用
收藏
页码:1599 / 1604
页数:6
相关论文
共 23 条
[1]   MATERNAL HYPEROXYGENATION IN THE TREATMENT OF INTRAUTERINE GROWTH-RETARDATION [J].
BATTAGLIA, C ;
ARTINI, PG ;
DAMBROGIO, G ;
GALLI, PA ;
SEGRE, A ;
GENAZZANI, AR .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1992, 167 (02) :430-435
[2]   HUMAN PLACENTA EXPRESSES ENDOTHELIN GENE AND CORRESPONDING PROTEIN IS EXCRETED IN URINE IN INCREASING AMOUNTS DURING NORMAL-PREGNANCY [J].
BENIGNI, A ;
GASPARI, F ;
ORISIO, S ;
BELLIZZI, L ;
AMUSO, G ;
FRUSCA, T ;
REMUZZI, G .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1991, 164 (03) :844-848
[3]   EVIDENCE FOR AN EFFECTOR ROLE OF ENDOTHELIN IN CLOSURE OF THE DUCTUS-ARTERIOSUS AT BIRTH [J].
COCEANI, F ;
KELSEY, L ;
SEIDLITZ, E .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1992, 70 (07) :1061-1064
[4]   PHYSIOLOGY AND MANAGEMENT OF INTRAUTERINE GROWTH-RETARDATION - A BIOLOGIC APPROACH WITH FETAL BLOOD-SAMPLING [J].
COX, WL ;
DAFFOS, F ;
FORESTIER, F ;
DESCOMBEY, D ;
AUFRANT, C ;
AUGER, MC ;
GASCHARD, JC .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1988, 159 (01) :36-41
[5]  
FOK RY, 1990, OBSTET GYNECOL, V75, P578
[6]   ENDOTHELIN - PRESENCE IN HUMAN UMBILICAL VESSELS, HIGH-LEVELS IN FETAL BLOOD AND POTENT CONSTRICTOR EFFECT [J].
HAEGERSTRAND, A ;
HEMSEN, A ;
GILLIS, C ;
LARSSON, O ;
LUNDBERG, JM .
ACTA PHYSIOLOGICA SCANDINAVICA, 1989, 137 (04) :541-542
[7]   CHARACTERIZATION, LOCALIZATION AND ACTIONS OF ENDOTHELINS IN UMBILICAL VESSELS AND PLACENTA OF MAN [J].
HEMSEN, A ;
GILLIS, C ;
LARSSON, O ;
HAEGERSTRAND, A ;
LUNDBERG, JM .
ACTA PHYSIOLOGICA SCANDINAVICA, 1991, 143 (04) :395-404
[8]   PLASMA-IMMUNOREACTIVE ENDOTHELIN-1 CONCENTRATION IN HUMAN FETAL BLOOD - ITS RELATION TO ASPHYXIA [J].
ISOZAKIFUKUDA, Y ;
KOJIMA, T ;
HIRATA, Y ;
ONO, A ;
SAWARAGI, S ;
SAWARAGI, I ;
KOBAYASHI, Y .
PEDIATRIC RESEARCH, 1991, 30 (03) :244-247
[9]   ENDOTHELIAL VASOACTIVE MEDIATORS IN PREECLAMPSIA [J].
KRAAYENBRINK, AA ;
DEKKER, GA ;
VANKAMP, GJ ;
VANGEIJN, HP .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1993, 169 (01) :160-165
[10]   NEONATAL OUTCOME AFTER PREGNANCY COMPLICATED BY ABNORMAL VELOCITY WAVE-FORMS IN THE UMBILICAL ARTERY [J].
MCDONNELL, M ;
SERRASERRA, V ;
GAFFNEY, G ;
REDMAN, CWG ;
HOPE, PL .
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 1994, 70 (02) :F84-F89