Linking nutrition to genomics

被引：15

作者：

Bauer, M ^{[1
]}

Hamm, A ^{[1
]}

Pankratz, MJ ^{[1
]}

机构：

[1] Forschungszentrum Karlsruhe, Inst Genet, D-76021 Karlsruhe, Germany

来源：

BIOLOGICAL CHEMISTRY | 2004年 / 385卷 / 07期

关键词：

caloric restriction; hepatic expression profiling; lifespan prolongation; metabolic signaling; microarray analysis; nutrition response;

D O I：

10.1515/BC.2004.073

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The new scientific field of nutrigenomics utilizes genomic tools, like microarrays, to analyze metabolic adaptations induced by variations in nutritional status. Here we describe how transcriptional regulation patterns caused by nutritional changes can be identified using gene expression profiling. This includes technical remarks on microarray analysis and data processing, as well as giving biological meaning to statistically solid data. We highlight our recent findings of transcriptional regulation of genes representing specific signaling and metabolic pathways in mouse liver under starvation. The results show strong correlations to previously identified responses to caloric restriction, which can be linked to lifespan extension.

引用

页码：593 / 596

页数：4

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