Engineered Micro-Objects as Scaffolding Elements in Cellular Building Blocks for Bottom-Up Tissue Engineering Approaches

被引：93

作者：

Leferink, A. ^{[1
]}

Schipper, D. ^{[1
]}

Arts, E. ^{[1
]}

Vrij, E. ^{[1
]}

Rivron, N. ^{[1
]}

Karperien, M. ^{[1
]}

Mittmann, K. ^{[2
]}

van Blitterswijk, C. ^{[1
]}

Moroni, L. ^{[1
]}

Truckenmueller, R. ^{[1
]}

机构：

[1] Univ Twente, MIRA Inst Biomed Technol & Tech Med, Dept Tissue Regenerat, NL-7522 NB Enschede, Netherlands

[2] Munster Univ Appl Sci, Fachbereich Phys Tech, D-48565 Steinfurt, Germany

来源：

ADVANCED MATERIALS | 2014年 / 26卷 / 16期

关键词：

bottom-up tissue engineering; micro-objects; human mesenchymal stromal cells; cell aggregates; biofabrication; IN-VITRO; BIOMATERIALS; SPHEROIDS; DESIGN;

D O I：

10.1002/adma.201304539

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A material-based bottom-up approach is proposed towards an assembly of cells and engineered micro-objects at the macroscale. We show how shape, size and wettability of engineered micro-objects play an important role in the behavior of cells on these objects. This approach can, among other applications, be used as a tool to engineer complex 3D tissues of clinically relevant size. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：2592 / 2599

页数：8

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