The Ras/Raf/MAPK pathway

被引:256
作者
Molina, Julian R. [1 ]
Adjei, Alex A. [1 ]
机构
[1] Mayo Clin, Div Med Oncol, Rochester, MN 55905 USA
关键词
D O I
10.1097/01243894-200601000-00004
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:7 / 9
页数:3
相关论文
共 25 条
[1]   Blocking oncogenic Ras signaling for cancer therapy [J].
Adjei, AA .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2001, 93 (14) :1062-1074
[2]   Ras activation of the Raf kinase: Tyrosine kinase recruitment of the MAP kinase cascade [J].
Avruch, J ;
Khokhlatchev, A ;
Kyriakis, JM ;
Luo, ZJ ;
Tzivion, G ;
Vavvas, D ;
Zhang, XF .
RECENT PROGRESS IN HORMONE RESEARCH, VOL 56, 2001, 56 :127-155
[3]   RAS GENES [J].
BARBACID, M .
ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :779-827
[4]   THE EPIDERMAL GROWTH-FACTOR [J].
BOONSTRA, J ;
RIJKEN, P ;
HUMBEL, B ;
CREMERS, F ;
VERKLEIJ, A ;
HENEGOUWEN, PVE .
CELL BIOLOGY INTERNATIONAL, 1995, 19 (05) :413-430
[5]   GTPases and T cell activation [J].
Cantrell, DA .
IMMUNOLOGICAL REVIEWS, 2003, 192 (01) :122-130
[6]  
Cary LA, 1999, HISTOL HISTOPATHOL, V14, P1001, DOI 10.14670/HH-14.1001
[7]   Mutations of the BRAF gene in human cancer [J].
Davies, H ;
Bignell, GR ;
Cox, C ;
Stephens, P ;
Edkins, S ;
Clegg, S ;
Teague, J ;
Woffendin, H ;
Garnett, MJ ;
Bottomley, W ;
Davis, N ;
Dicks, N ;
Ewing, R ;
Floyd, Y ;
Gray, K ;
Hall, S ;
Hawes, R ;
Hughes, J ;
Kosmidou, V ;
Menzies, A ;
Mould, C ;
Parker, A ;
Stevens, C ;
Watt, S ;
Hooper, S ;
Wilson, R ;
Jayatilake, H ;
Gusterson, BA ;
Cooper, C ;
Shipley, J ;
Hargrave, D ;
Pritchard-Jones, K ;
Maitland, N ;
Chenevix-Trench, G ;
Riggins, GJ ;
Bigner, DD ;
Palmieri, G ;
Cossu, A ;
Flanagan, A ;
Nicholson, A ;
Ho, JWC ;
Leung, SY ;
Yuen, ST ;
Weber, BL ;
Siegler, HF ;
Darrow, TL ;
Paterson, H ;
Marais, R ;
Marshall, CJ ;
Wooster, R .
NATURE, 2002, 417 (6892) :949-954
[8]  
Dergham ST, 1997, INT J PANCREATOL, V21, P127
[9]   Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib [J].
Eberhard, DA ;
Johnson, BE ;
Amler, LC ;
Goddard, AD ;
Heldens, SL ;
Herbst, RS ;
Ince, WL ;
Jänne, PA ;
Januario, T ;
Johnson, DH ;
Klein, P ;
Miller, VA ;
Ostland, MA ;
Ramies, DA ;
Sebisanovic, D ;
Stinson, JA ;
Zhang, YR ;
Seshagiri, S ;
Hillan, KJ .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (25) :5900-5909
[10]   High frequency of Ki-ras amplification and p53 gene mutations in adenocarcinomas of the human esophagus [J].
Galiana, C ;
Lozano, JC ;
Bancel, B ;
Nakazawa, H ;
Yamasaki, H .
MOLECULAR CARCINOGENESIS, 1995, 14 (04) :286-293