Cancer Stem Cells: A New Paradigm for Understanding Tumor Growth and Progression and Drug Resistance

被引：121

作者：

Gangemi, Rosaria ^{[2
]}

Paleari, Laura ^{[1
]}

Orengo, Anna Maria ^{[2
]}

Cesario, Alfredo ^{[3
,4
]}

Chessa, Leonardo ^{[5
]}

Ferrini, Silvano ^{[2
]}

Russo, Patrizia ^{[1
]}

机构：

[1] Natl Inst Canc Res, Lung Canc Unit, I-16132 Genoa, Italy

[2] Natl Inst Canc Res, Immunol Therapy Lab, I-16132 Genoa, Italy

[3] Catholic Univ, Thorac Surg Unit, Rome, Italy

[4] IRCCS San Raffaele, Rome, Italy

[5] San Martino Hosp, Thorac Surg Unit, Genoa, Italy

来源：

CURRENT MEDICINAL CHEMISTRY | 2009年 / 16卷 / 14期

关键词：

ACUTE MYELOID-LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; SMALL-MOLECULE INHIBITOR; MEDIATES RADIATION-RESISTANCE; SIDE-POPULATION; MULTIDRUG-RESISTANCE; INITIATING CELLS; HEDGEHOG PATHWAY; SIGNALING PATHWAYS; PROGENITOR CELLS;

D O I：

10.2174/092986709788186147

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Normal somatic stem cells (SC) are naturally resistant to chemotherapeutic agents due to their expression of various membrane transporter molecules (such as MDR-1), detoxifying enzymes and DNA repair proteins. In addition, they also have a slow rate of cell turnover and therefore escape from chemotherapeutic agents that target rapidly replicating cells. Cancer stem cells (CSC), being the mutated counterparts of normal SC, also have similar properties, which allow them to survive therapy. These surviving CSC then repopulate the tumor, causing relapse. The purpose of this review is to understand the most current research into the cellular and molecular biology of CSC. Topics that will be explored are the origin of CSC, the CSC niche, the regulation of self-renewal in normal and cancer SC, and CSC as therapeutic targets.

引用

页码：1688 / 1703

页数：16

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