Analysis of ahpC gene mutations in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis

被引：86

作者：

Kelley, CL ^{[1
]}

Rouse, DA ^{[1
]}

Morris, SL ^{[1
]}

机构：

[1] US FDA,CBER,LAB MYCOBACTERIA,BETHESDA,MD 20892

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 09期

关键词：

D O I：

10.1128/AAC.41.9.2057

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The ahpC genes of 57 clinical isolates and one in vitro mutant of Mycobacterium tuberculosis were evaluated by nucleotide sequence analyses. Although compensatory ahpC promoter mutations were identified in 8 catalase-negative, katG-defective strains, the ahpC genes of 25 catalase-positive, isoniazid-resistant isolates and 25 drug-sensitive strains were not altered.

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收藏

页码：2057 / 2058

页数：2

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