Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene

被引：172

作者：

Speck, SH

Chatila, T

Flemington, E

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT PEDIAT,ST LOUIS,MO 63110

[2] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115

来源：

TRENDS IN MICROBIOLOGY | 1997年 / 5卷 / 10期

关键词：

D O I：

10.1016/S0966-842X(97)01129-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The switch from latent infection to virus replication in Epstein-Barr virus (EBV)-infected B cells is initiated by expression of the viral BZLF1 gene. Recent studies have identified the key cellular transcription factors involved in regulating this switch in viral programs and the signal transduction pathways to which they respond. Understanding this switch may facilitate development of strategies to interfere with EBV infection.

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页码：399 / 405

页数：7

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