Patterning neuronal connections by chemorepulsion: the semaphorins

被引:94
作者
Mark, MD [1 ]
Lohrum, M [1 ]
Puschel, AW [1 ]
机构
[1] MAX PLANCK INST HIRNFORSCH,NEUROCHEM ABT,D-60528 FRANKFURT,GERMANY
关键词
collapsin; spinal cord; axon guidance; growth cone; sensory afferent;
D O I
10.1007/s004410050934
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Axonal growth cones navigate long distances along specific pathways to establish complex patterns of neuronal connections. A growing number of signals have been identified that participate in these steering decisions. This review will concentrate on a large and growing family of chemorepellents, the semaphorins. This family contains both secreted and membrane-bound proteins expressed in many neuronal and non-neuronal tissues of invertebrates and vertebrates. Ongoing studies have given us a better understanding of how their highly conserved signalling system is involved in patterning neuronal connections.
引用
收藏
页码:299 / 306
页数:8
相关论文
共 53 条
[1]   A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis [J].
Adams, RH ;
Betz, H ;
Puschel, AW .
MECHANISMS OF DEVELOPMENT, 1996, 57 (01) :33-45
[2]   ATTRACTIVE AXON GUIDANCE MOLECULES [J].
BAIER, H ;
BONHOEFFER, F .
SCIENCE, 1994, 265 (5178) :1541-1542
[3]   MAMMALIAN SUBTILISINS - THE LONG-SOUGHT DIBASIC PROCESSING ENDOPROTEASES [J].
BARR, PJ .
CELL, 1991, 66 (01) :1-3
[4]   Semaphorin III Is needed for normal patterning and growth of nerves, bones and heart [J].
Behar, O ;
Golden, JA ;
Mashimo, H ;
Schoen, FJ ;
Fishman, MC .
NATURE, 1996, 383 (6600) :525-528
[5]  
Byk T, 1996, J NEUROSCI, V16, P688
[6]  
Cajal S. R., 1995, HIST NEUROSCIENCE
[7]   ALCELAPHINE HERPESVIRUS TYPE-1 HAS A SEMAPHORIN-LIKE GENE [J].
ENSSER, A ;
FLECKENSTEIN, B .
JOURNAL OF GENERAL VIROLOGY, 1995, 76 :1063-1067
[8]   THE ORGANIZATION OF F-ACTIN AND MICROTUBULES IN GROWTH CONES EXPOSED TO A BRAIN-DERIVED COLLAPSING FACTOR [J].
FAN, JH ;
MANSFIELD, SG ;
REDMOND, T ;
GORDONWEEKS, PR ;
RAPER, JA .
JOURNAL OF CELL BIOLOGY, 1993, 121 (04) :867-878
[9]   LOCALIZED COLLAPSING CUES CAN STEER GROWTH CONES WITHOUT INDUCING THEIR FULL COLLAPSE [J].
FAN, JH ;
RAPER, JA .
NEURON, 1995, 14 (02) :263-274
[10]   GROWTH-CONE COLLAPSE - TOO MUCH OF A GOOD THING [J].
FAWCETT, JW .
TRENDS IN NEUROSCIENCES, 1993, 16 (05) :165-167