Solvents inducing oxidation of hydroxylamines

被引：13

作者：

Horiyama, S

Suwa, K

Yamaki, M

Kataoka, H

Katagi, T

Takayama, M

Takeuchi, T

机构：

[1] Mukogawa Womens Univ, Fac Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan

[2] Yokohama City Univ, Grad Sch Sci, Kanazawa Ku, Yokohama, Kanagawa 2360027, Japan

[3] Nara Womens Univ, Fac Sci, Dept Chem, Kitauoyanishi, Nara 6308506, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 07期

关键词：

hydroxylamine; oxidation; LC-MS; NMR;

D O I：

10.1248/cpb.50.996

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Hydroxylamines gradually undergo oxidation to their oximes on being dissolved in organic solvent (e.g. methanol). This phenomenon was followed by H-1-NMR and liquid chromatography-mass spectrometry (LC-MS). The oxidation rate was estimated from the peak area observed on the mass chromatogram at the protonated molecule or fragment ion on LC-atmospheric pressure chemical ionization (APCI)-MS. The results showed that the oxidation rate of hydroxylamines depended on the solvent type.

引用

页码：996 / 1000

页数：5

共 14 条

[1]

IDENTIFICATION, PROPERTIES AND ANALYSIS OF N-HYDROXYAMPHETAMINE METABOLITE OF AMPHETAMINE [J].